Yes you can. All you need is all of your images in a database (as filenames or pathes) – MyDataMerge offers multiple options to adjust the filePath in the Datasource element settings of type “Replace with image”. Then you can predefine a layout with multiple instances (Multiple records per page: Layout provided) and merge all of your images. You can in addition also do an inline merge, so all of your images are merged inside one frame so you can profit of story flowing around other content.
Note: In a future update we will add the function to drop a folder of images instead of a database to make that even more easier.